Florida, the biggest prize among the five states holding presidential primaries Tuesday, rewarded Donald Trump over its own senator, Marco Rubio, and gave Democrat Hillary Clinton a huge victory over Bernie Sanders.
Trump easily beat Rubio, claiming victory on Twitter well before all of the state's polls closed. Rubio waited until poll closing to concede and in the same speech dropped out of the race for the Republican nomination. As he congratulated Trump, his supporters booed loudly. Rubio responded, "No! No! No!''
"It is not God's plan that I be president in 2016, or maybe even ever,'' Rubio said. "I ask the American people, do not give in to the fear. Do not give in to the frustration. We can disagree about public policy, we can disagree about it vibrantly, passionately, but we are a hopeful people, and we have every right to be hopeful.''
Trump won all 99 Republican delegates. Clinton will take most of the state's 214 Democratic delegates, which will be awarded proportionally.
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Florida's primary election could seal nominations for Clinton, Trump ▼
Latest on Florida, Illinois, Missouri, North Carolina, Ohio primaries
All times EDT
11 p.m. Donald Trump, Bernie Sanders leading in Missouri primaries, but races too close to call.
10 p.m. Donald Trump speaking to supporters.
9:45 p.m. Donald Trump wins Illinois, North Carolina primaries, awaiting speech.
9:20 p.m. - John Kasich speaks to supporters following primary victory in Ohio.
9 p.m. - Hillary Clinton speaks to supporters.
8:45 p.m. - Ohio Gov. John Kasich has won the GOP presidential primary in his home state.
8:40 p.m. - Hillary Clinton wins Democratic presidential primary in Ohio.
8:25 p.m. - Hillary Clinton wins the Democratic presidential primary in North Carolina, adding a second win to her Tuesday tally over rival Bernie Sanders.
8:15 p.m. - Marco Rubio speaks to supporters, announces he is suspending his campaign for president. Rubio says he is not on the "winning side" in the GOP presidential race.
8 p.m. - Donald Trump and Hillary Clinton win presidential primary elections in Florida.
7:22 p.m. - Clinton, Trump hold early leads in Florida Primary.
7 p.m. - Polls close in the Tampa Bay and Central Florida areas.
11:02 a.m. - House Speaker Paul Ryan says all candidates have an obligation to do what they can to provide an atmosphere of harmony at campaign events and not incite violence.
His comments Tuesday come as attacks have marred rallies led by GOP front-runner Donald Trump. The candidate canceled an event in Chicago on Friday night over protests.
Ryan told reporters that there is a concerted effort by those on the left to disrupt the rallies and he condemned that. At the same time he said candidates should ensure they are appealing to people's best ideals and trying to unite the country to fix the nation's problems.
Pressed on support for the eventual nominee, Ryan said that is a decision the GOP primary voters will make.
10:20 a.m. - Ohio Gov. John Kasich says he'll have plenty to say about one GOP candidate in particular - Donald Trump - after Tuesday's critical primaries in five states.
Speaking to reporters in Genoa, Ohio, after voting for himself for president, Kasich said he'll be "forced, going forward, to talk about some of the deep concerns" he has about Trump's campaign. He said Trump's combative comments at rallies and his comments about women are of particular concern.
Speaking out would not be "designed to be negative as much as it is to point out things that have been deeply disturbing."
Kasich concluded that whatever happens in Tuesday's contests, he appreciates the opportunity and the attention.
He added, "I just want to be a good guy, helping my country."
9:44 a.m. - Donald Trump has posted a big win in the GOP caucus on the Northern Mariana Islands.
The party says the billionaire businessman won almost 73 percent of the vote in Tuesday's caucus. He will get all nine delegates from the U.S. territory.
Texas Sen. Ted Cruz came in second with 24 percent of the vote, while Ohio Gov. John Kasich and Florida Sen. Marco Rubio finished a distant third and fourth, respectively.
7:10 a.m. - Republican presidential candidate Donald Trump is backing away from a suggestion that he might cover legal costs for a supporter who was involved in an altercation with another person at a rally last week in North Carolina.
7:05 a.m. - Technical issues reported at several Orange County polling locations
7 a.m. - Polls open
Florida's primary election could seal nominations for Clinton, Trump
Four other states — Illinois, Missouri, North Carolina and Ohio — hold presidential primaries today, but it's Florida's 99 Republican delegates and 214 pledged Democratic delegates that could all but determine who's on the presidential ballot in November.
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GOP and Democratic front-runners Donald Trump and Hillary Clinton enter Tuesday in comfortable leads among likely Florida voters, according to an exclusive statewide News 13/Bay News 9 poll conducted a week ago. About 42 percent of GOP voters polled responded that they would vote for Trump, if the presidential primary were held that day, while 61 percent of Democratic voters would vote for Clinton.
For Sen. Marco Rubio, Tuesday could be his campaign swan song if he doesn't win his home state. He says he's focused on winning the winner-take-all GOP primary, dismissing several polls that show him trailing Trump.
Rubio is predicting a "close election" but says he's going to win. Rubio also said he's not had any talks or meetings with Cruz or John Kasich to team up to defeat Trump and is "not open" to any such talk about joining forces.
He said the best way to stop Trump would be for him to win the nomination.
"The best way to do it is to win an election here in Florida. That's the best way to do it," Rubio told CNN. "I'm open to one thing, and that's winning Florida on Tuesday and going on from there and getting the delegates I need to be the nominee, or at least more delegates than anybody else."
This week, Trump and Cruz each picked up endorsements from former GOP candidates Ben Carson and Carly Fiorina, respectively.
On the Democratic side, Clinton and Sen. Bernie Sanders crisscrossed the state for rallies Thursday, a day after Sanders won an upset victory in Michigan's primary. On Thursday, the presidential hopefuls sparred in a debate in Miami over immigration.
In addition to the presidential preference primary Tuesday, scores of cities and towns will hold elections for commissions seats and referendums. Florida is a closed primary state, so voters registered as "no party affiliation" won't be able to vote in the presidential preference primary, though if they live in a municipality that's holding a nonpartisan race or referendum, they can cast their ballot for that.
Team coverage of Tuesday's elections begins at 5 p.m., and full election coverage with our analysts begins at 7 p.m. All candidate speeches will be carried live on TV.
Information from CNN and The Associated Press was used in this report.