Senate Democrats are in the middle of a 24-hour long speak out on the floor to explain their issues with confirming Betsy DeVos as education secretary. The official vote to confirm DeVos is scheduled for Tuesday and Democrats hope they can convince one more Republican to vote against her.

The way the vote would stand now, two Republicans have said they would vote against DeVos, which would likely make it a tie. The two Republican senators, Sen. Lisa Murkowski of Alaska and Susan Collins of Maine, are breaking ranks and are expected to vote against DeVos.

However, with Vice President Mike Pence as the tie breaker, they need one more Republican if they want to block DeVos from the position.

There has been strong opposition against her as Democrats cite inexperience in the public education field, her strong advocacy of charter schools and even accusations of plagiarism. DeVos is a Michigan billionaire and champion of school vouchers and charter schools. She was an architect of Detroit's charter school system. But she has little to no experience with public schools.

Washington Democratic Sen. Patty Murray has been one of the most vocal Democrats against DeVos.

"She would enter this job as the most controversial and embattled secretaries in the history of this department. She would start this job with no credibility inside the agency she is supposed to lead, with no influence in Congress, as the punch-line in late-night comedy shows and without the confidence of the American people," he said.

Michigan Democrat Sen. Debbie Stabenow told CNN on Monday they may have an additional Republican voting "no," but did not name who it was.

Democrats in the Senate went through the night to hold up the nomination of DeVos for education secretary. But unless a Republican senator breaks ranks and votes no, DeVos will likely be confirmed Tuesday.

Senate phone lines have been clogged with calls from parents and teachers demanding the Senate reject DeVos' nomination, calling her unqualified to hold the position. 

In addition to not having public school experience that has caused many to have concerns about her, during her Senate hearing DeVos stumbled on some basic policy questions and education information. She suggested cutting education funding and privatizing public schools.

DeVos also tripped herself up on a question about whether the federal government should enforce a law that protects students with disabilities, suggesting that the states should decide whether to enforce the law making sure students with disabilities can get an education. 

She said after the meeting that she was confused about the law and she would enforce it.

DeVos also, to much derision, said schools should be allowed to have guns in schools in case they need to protect students from "potential grizzlies."

Sen. Bill Nelson, D-Florida says he will not vote for DeVos, but Sen. Marco Rubio, R-Florida, says he will. 

DeVos will likely be confirmed Tuesday, but it will require Vice President Mike Pence to come in and perform a Constitutional duty rarely seen in the U.S. Senate: breaking a tie vote.

Democrats will use the same tactic with other cabinet nominees Republicans hope to push through this week, which could result in a lot of late nights.

Information from the Associated Press contributed to this report.