Democrats in the Senate will go through the night to hold up the nomination of Betsy DeVos for education secretary. But unless a Republican senator breaks ranks and votes no, DeVos will likely be confirmed Tuesday.

Senate phone lines have been clogged with calls from parents and teachers demanding the Senate reject DeVos' nomination, calling her unqualified to hold the position. 

Two Republican senators, Sen. Lisa Murkowski of Alaska and Susan Collins of Maine are breaking ranks and will vote against DeVos.

DeVos is a Michigan billionaire and champion of school vouchers and charter schools. She was an architect of Detroit's charter school system. But she has little to no experience with public schools.

In addition, during her Senate hearing DeVos stumbled on some basic policy questions and education information. She suggested cutting education funding and privatizing public schools.

DeVos also stumbled on a question about whether the federal government should enforce a law that protects students with disabilities, suggesting that the states should decide whether to enforce the law making sure students with disabilities can get an education. 

She said after the meeting that she was confused about the law and she would enforce it.

DeVos also, to much derision, said schools should be allowed to have guns in schools in case they need to protect students from "potential grizzlies."

Sen. Bill Nelson, D-Florida says he will not vote for DeVos, but Sen. Marco Rubio, R-Florida, says he will. 

DeVos will likely be confirmed Tuesday, but it will require Vice President Mike Pence to come in and perform a Constitutional duty rarely seen in the U.S. Senate: breaking a tie vote.

Democrats will use the same tactic with other cabinet nominees Republicans hope to push through this week, which could result in a lot of late nights.

Information from the Associated Press contributed to this report.